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Prognostic markers in metastatic cutaneous squamous cell carcinoma of the head and neck
Author(s) -
Hirshoren Nir,
Danne Julia,
Dixon Benjamin John,
Magarey Matthew,
Kleid Stephen,
Webb Angela,
Tiong Albert,
Corry June,
Gyorki David
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24683
Subject(s) - medicine , lymph node , hazard ratio , lymphadenectomy , lymph , head and neck , proportional hazards model , head and neck squamous cell carcinoma , neck dissection , oncology , multivariate analysis , basal cell , head and neck cancer , carcinoma , cancer , pathology , surgery , confidence interval
Background The minority of head and neck cutaneous squamous cell carcinomas (SCC) metastasize to regional lymph nodes. The purpose of this study was to describe the clinical outcomes and prognostic factors for patients with node‐positive head and neck cutaneous SCC who underwent lymphadenectomy. Methods We conducted a retrospective single center study using the Kaplan–Meier method for the investigation of the overall survival (OS) and locoregional control rates. The Cox proportional hazards model was evaluated to identify prognostic factors. Results The median number of positive lymph nodes from 149 lymphadenectomies was 2 in the neck and 1 in the parotid gland. The 5‐year OS and locoregional control rates were 50% and 77%, respectively. OS was worse among older patients (hazard ratio [HR], 1.04; p = .015), immunosuppressed patients (HR, 2.06; p = .034), and patients with a high total lymph node ratio (calculated from the number of positive lymph nodes divided by the total number of nodes; multivariate analysis [MVA]; HR, 1.13; p = .019). Conclusion Low total lymph node ratio is associated with improved outcomes in node‐positive head and neck cutaneous SCC. © 2017 Wiley Periodicals, Inc. Head Neck 39: 772–778, 2017