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Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy
Author(s) -
Quinlan–Davidson Sean R.,
Morrison William H.,
Myers Jeffrey N.,
Gunn Gary B.,
William William N.,
Beadle Beth M.,
Skinner Heath D.,
Gillenwater Ann M.,
Frank Steven J.,
Phan Jack,
Johnson Faye M.,
Fuller Clifton D.,
Zafereo Mark E.,
Rosenthal David I.,
Garden Adam S.
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24666
Subject(s) - medicine , radiation therapy , salvage therapy , head and neck cancer , retrospective cohort study , head and neck , surgery , multimodal therapy , cohort , oral cavity , chemotherapy , cancer , overall survival , oncology , orthodontics
Background We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. Methods A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. Results Seventy‐eight patients were analyzed. All patients had salvage surgery and intensity‐modulated radiotherapy (IMRT) and 74% had chemotherapy. Five‐year overall survival, recurrence‐free survival, and locoregional control rates were 59%, 60%, and 74%, respectively. Conclusion Outcomes of radiation naïve patients with recurrent OCC are fair, and seem similar with patients with locally advanced nonrecurrent OCC treated with multimodal therapy. © 2016 Wiley Periodicals, Inc. Head Neck 39: 633–638, 2017