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Prognostic value of the seventh AJCC/UICC TNM classification of intestinal‐type ethmoid adenocarcinoma: Systematic review and risk prediction model
Author(s) -
Fiaux–Camous Domitille,
Chevret Sylvie,
Oker Natalie,
Turri–Zai Mario,
Lombardi Davide,
Choussy Olivier,
Duprez Frederic,
Jorissen Marc,
de Gabory Ludovic,
Malard Olivier,
Herman Philippe,
Nicolai Piero,
Castelnuovo Paolo,
Verillaud Benjamin
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24663
Subject(s) - medicine , oncology , homogeneous , adenocarcinoma , survival analysis , recursive partitioning , cancer , mathematics , combinatorics
Background The purpose of this study was to propose a prognostic classification of intestinal‐type adenocarcinoma (ITAC) based on literature search and prognostic modeling of cohort data. Methods We first conducted a literature search to assess the homogeneity of the reported estimates of 5‐year survival and to identify the influence of T classification. We then pooled prospective data from 3 large French and Italian series to predict time to all‐cause mortality. The sample was randomly split to derive and then to validate the proposed prognostic model. Results Literature analysis confirmed the heterogeneity in 5‐year survival rates, partly explained in subsets of homogeneous T‐values. The sample included 223 patients, randomly separated into a derivation ( n = 141) and a validation set ( n = 82). Invasion of the sphenoid lateral and/or posterior walls and dura/cerebral invasion were systematically associated with a poor survival. Conclusion The incorporation of the invasion of the sphenoid lateral or posterior walls should be considered for ITAC management and prognostication. © 2017 Wiley Periodicals, Inc. Head Neck 39: 668–678, 2017