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Core‐needle biopsy versus repeat fine‐needle aspiration for thyroid nodules initially read as atypia/follicular lesion of undetermined significance
Author(s) -
Choi Young Jun,
Baek Jung Hwan,
Suh Chong Hyun,
Shim Woo Hyun,
Jeong Boseul,
Kim Jae Kyun,
Song Dong Eun,
Kim Tae Yong,
Chung KiWook,
Lee Jeong Hyun
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24597
Subject(s) - medicine , atypia , fine needle aspiration , thyroid nodules , biopsy , thyroid , radiology , odds ratio , lesion , pathology
Background The purpose of this study was to evaluate the role of core‐needle biopsy (CNB) by comparing the results of CNB and repeat fine‐needle aspiration (FNA) for thyroid nodules that are initially read as atypia/follicular lesion of undetermined significance (AUS/FLUS) on FNA. Methods Among 2631 initial AUS/FLUS FNA results, 505 consecutive nodules (295 repeat FNAs and 210 CNBs) were retrospectively analyzed. The primary outcome was inconclusive (ie, nondiagnostic or AUS/FLUS). The secondary outcomes included inconclusive results of the subcategory, risk factors for inconclusive results, and diagnostic performance. Results CNB demonstrated significantly fewer inconclusive results than repeat FNA for the overall nodules (40.9% vs 63%; p < .001). Repeat FNA and group FLUS were significant risk factors for inconclusive results (odds ratio = 1.92; p =.001 and odds ratio = 2.08; p <.001, respectively). All diagnostic performances using CNB were higher than repeat FNAs. Conclusion CNB is more useful than repeat FNAs for reducing inconclusive results and improving the diagnostic performance of thyroid nodules with initial AUS/FLUS FNA results. © 2016 Wiley Periodicals, Inc. Head Neck 39: 361–369, 2017