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Predicting lymph node metastasis in patients with papillary thyroid carcinoma by vascular index on power Doppler ultrasound
Author(s) -
Lee Ji Hye,
Shin Hyun Joo,
Yoon Jung Hyun,
Kim EunKyung,
Moon Hee Jung,
Lee Hye Sun,
Kwon Hyeong Ju,
Kwak Jin Young
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24592
Subject(s) - medicine , vascularity , thyroid carcinoma , lymph node , metastasis , lymph node metastasis , pathology , thyroid cancer , oncology , lymph , vascular endothelial growth factor , thyroid , cancer , vegf receptors
Background For patients with papillary thyroid carcinoma (PTC), lymph node metastasis is associated with an increased recurrence rate. The purpose of this study was to investigate whether the vascular endothelial growth factor (VEGF), microvessel density (MVD), and vascular index (VI) can predict lymph node metastasis in patients with PTC. Methods From January 2011 to October 2011, 202 patients with PTCs underwent preoperative staging ultrasound evaluation. To evaluate vascularity, we measured the VI, VEGF expression, and MVD. Results The VI was significantly correlated with MVD ( p = .009). On multivariate analysis, young age showed a significant correlation with lymph node metastasis ( p < .001; p < .001; p < .001). However, the other clinicopathologic features, VEGF, MVD, and VI failed to show any significant correlations with lymph node metastasis. Conclusion Although the VI showed significant correlation with MVD, it was not significantly correlated to lymph node metastasis. © 2016 Wiley Periodicals, Inc. Head Neck 39: 334–340, 2017