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Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer
Author(s) -
Noorlag Rob,
Boeve Koos,
Witjes Max J. H.,
Koole Ronald,
Peeters Ton L. M.,
Schuuring Ed,
Willems Stefan M.,
Es Robert J. J.
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24584
Subject(s) - occult , cyclin d1 , cancer research , cancer , metastasis , medicine , nodal , oncology , biology , pathology , cell cycle , alternative medicine
Background Accurate nodal staging is pivotal for treatment planning in early (stage I–II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1 , Fas‐associated death domain ( FADD ), and CTTN , is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited. Methods In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases. Results CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers. Conclusion Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. © 2016 Wiley Periodicals, Inc. Head Neck 39: 326–333, 2017