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Artificial nutrition dependence after cetuximab versus cisplatin combined with radiotherapy for advanced head and neck cancer: A propensity score–matched analysis
Author(s) -
Ishimaru Miho,
Ono Sachiko,
Suzuki Sayaka,
Matsui Hiroki,
Fushimi Kiyohide,
Yasunaga Hideo
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24583
Subject(s) - cetuximab , propensity score matching , medicine , head and neck cancer , confidence interval , odds ratio , radiation therapy , oncology , cisplatin , chemoradiotherapy , concomitant , cancer , chemotherapy , colorectal cancer
Background The purpose of this study was to compare the effect of cetuximab‐based radiotherapy (RT) with cisplatin‐based concomitant chemoradiotherapy (CCRT) on artificial nutrition dependence in locoregional advanced head and neck cancer. Methods We identified patients treated with cetuximab‐based RT or CCRT between 2012 and 2014 in a Japanese national database, and used propensity score‐matched analyses to evaluate artificial nutrition dependence for 30 days after starting chemotherapy and at hospital discharge. Results Of 3935 eligible patients, propensity score matching generated 250 pairs. Thirty‐day artificial nutrition dependence was significantly lower in the cetuximab‐based RT group than in the CCRT group (25.6% vs 35.2%; odds ratio [OR] = 0.67; 95% confidence interval [CI] = 0.46–0.97; p = .036). No significant difference in artificial nutrition dependence at hospital discharge was shown (6.2% vs 7.2%; OR = 1.07; 95% CI = 0.52–2.17; p = .861). Difference in duration of hospitalization was insignificant. Conclusion Cetuximab‐based RT may reduce short‐term artificial nutrition dependence compared to CCRT. © 2016 Wiley Periodicals, Inc. Head Neck 39: 320–325, 2017