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Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012
Author(s) -
Baek SeungKuk,
Lee MyungChul,
Hah J. Hun,
Ahn SoonHyun,
Son YoungIk,
Rho YoungSoo,
Chung PhilSang,
Lee YoonSe,
Koo Bon Seok,
Jung KwangYoon,
Lee ByungJoo
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24559
Subject(s) - medicine , thyroid carcinoma , anaplastic thyroid cancer , multivariate analysis , thyroid , oncology , anaplastic carcinoma , radiation therapy , chemoradiotherapy , thyroidectomy , surgery , thyroid cancer
Background The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors ( p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis ( p < 0.05). Conclusion Although ATC is a lethal neoplasm, long‐term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent. © 2016 Wiley Periodicals, Inc. Head Neck 39: 133–139, 2017