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Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis
Author(s) -
Wu Evan S.,
Park Jong Y.,
Zeitouni Joseph A.,
Gomez Carmen R.,
Reis Isildinha M.,
Zhao Wei,
Kwon Deukwoo,
Lee Eunkyung,
Nelson Omar L.,
Lin HuiYi,
Franzmann Elizabeth J.,
Savell Jason,
McCaffrey Thomas V.,
Goodwin W. Jarrard,
Hu Jennifer J.
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24420
Subject(s) - head and neck squamous cell carcinoma , medicine , hras , oncology , kras , cancer , odds ratio , head and neck cancer , confidence interval , somatic cell , gene , genetics , biology , colorectal cancer
Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and minorities have the worst survival. However, the molecular mechanisms underlying survival disparities have not been elucidated. Methods In a retrospective study, we assessed association between HNSCC early death (<2 years) and 208 somatic mutations of 10 cancer‐related genes in 214 patients: 98 non‐Hispanic whites (46%), 72 Hispanic whites (34%), and 44 African Americans (20%). Results Hispanic whites and African Americans had significantly higher mutation rates for EGFR , HRAS , KRAS , and TP53 . HNSCC early death was significantly associated with 3+ mutations (odds ratio [OR] = 2.78, 95% confidence interval [CI] = 1.16, 6.69), NOTCH1 mutations in non‐Hispanic whites (OR = 5.51; 95% CI = 1.22–24.83) and TP53 mutations in Hispanic whites (OR = 3.84; 95% CI = 1.08–13.68) in multivariable analysis adjusted for age, sex, tumor site, and tumor stage. Conclusion We have provided the proof‐of‐principal data to link racial/ethnic‐specific somatic mutations and HNSCC prognosis and pave the way for precision medicine to overcome HNSCC survival disparities. © 2016 Wiley Periodicals, Inc. Head Neck 38:1234–1241, 2016