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Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity
Author(s) -
Kundra Ajay,
Andrei Mirela,
Westra William,
Chaudhry Rashid,
Moussouris Harry,
Gohari Arash,
Wang Jen C.
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24418
Subject(s) - medicine , larynx , carcinoma , pathology , biopsy , head and neck , laryngectomy , anatomy , surgery
Background Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma. Methods and Results The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5/6 and p40. NUT protein immune‐stain positivity conclusively established the diagnosis of NUT midline carcinoma. Conclusion Absence of well‐known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis. © 2016 Wiley Periodicals, Inc. Head Neck 38:E2471–E2474, 2016