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Intestinal‐type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment
Author(s) -
Hoeben Ann,
van de Winkel Linda,
Hoebers Frank,
Kross Kenneth,
Driessen Chantal,
Slootweg Pieter,
Tjan–Heijnen Vivianne C. G.,
van Herpen Carla
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24416
Subject(s) - medicine , histopathology , nasal cavity , radiation therapy , paranasal sinuses , cancer , disease , oncology , pathology , surgery
Background Sinonasal intestinal‐type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized. Methods Articles on ITAC histopathology, molecular profile, and current treatment options of this specific tumor were identified and reviewed, using the electronic databases Pubmed, Medline, Cochrane, and Web of Science. Results This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC. Conclusion More translational research is needed to identify druggable targets that may lead to a personalized treatment plan in order to improve long‐term outcome in patients with locally advanced and/or metastasized ITAC. © 2016 Wiley Periodicals, Inc. Head Neck 38: First–1570, 2016