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Exponentially growing osteosarcoma of mandible with acromegaly
Author(s) -
Choi Nayeon,
Kim Seokhwi,
Cho Jungkyu,
Kim Byung Kil,
Cho Young Sang,
Jang Jeon Yeob,
Baek ChungHwan
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24394
Subject(s) - osteosarcoma , acromegaly , medicine , pituitary adenoma , somatostatin , malignancy , insulin like growth factor , hormone , endocrinology , growth factor , adenoma , oncology , pathology , growth hormone , receptor
Background Osteosarcoma of the head and neck is aggressive malignancy that might be affected by growth hormone. The purpose of this study was to demonstrate an unusual case of osteosarcoma with acromegaly. Methods and Results This case is about a 39‐year‐old woman with an osteosarcoma of the mandible, who had a history of exponential tumor growth in spite of chemotherapy at another hospital. She transferred to Samsung Medical Center and underwent a wide resection of tumor and free flap reconstruction. During postoperative care, a brain MRI and hormonal test revealed a growth hormone‐secreting pituitary adenoma, and then a transsphenoidal approach pituitary tumor removal was performed. Immunohistochemistry of the osteosarcoma indicated positive for insulin‐like growth factor (IGF)−2 and somatostatin receptor. Conclusion This study proved the IGF‐2 and somatostatin receptor from the osteosarcoma of the patient with acromegaly, and this could explain that the growth hormone secreting from the pituitary adenoma might be a risk factor of therapeutic intractability and growth acceleration of osteosarcoma. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2432–E2436, 2016