Human olfactory stem cells for injured facial nerve reconstruction in a rat model | Zendy

Batioglu–Karaaltin Aysegul | Zendy; Karaaltin Mehmet Veli | Zendy; Oztel Olga Nehir | Zendy; Ovali Ercument | Zendy; Sener Belit Merve | Zendy; Adatepe Turgut | Zendy; Yigit Ozgur | Zendy; Bozkurt Erol | Zendy; Baydar Serap Yesilkir | Zendy; Bagirova Melahat | Zendy; Uzun Nurten | Zendy; Allahverdiyev Adil | Zendy

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Human olfactory stem cells for injured facial nerve reconstruction in a rat model

Author(s) -

Batioglu–Karaaltin Aysegul,

Karaaltin Mehmet Veli,

Oztel Olga Nehir,

Ovali Ercument,

Sener Belit Merve,

Adatepe Turgut,

Yigit Ozgur,

Bozkurt Erol,

Baydar Serap Yesilkir,

Bagirova Melahat,

Uzun Nurten,

Allahverdiyev Adil

Publication year - 2016

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.24371

Subject(s) - stem cell , olfactory mucosa , facial nerve , anatomy , saline , olfactory system , medicine , biology , neuroscience , microbiology and biotechnology

Background The purpose of this study was to show the efficacy of olfactory stem cells for injured facial nerve reconstruction in a rat model. Methods Olfactory stem cells were isolated from the olfactory mucosa of human participants. A 2‐mm excision was performed on the right facial nerve of all rats. Reconstruction was performed with a conduit in group 1 ( n = 9); a conduit and phosphate‐buffered saline in group 2 ( n = 9); and a conduit and labeled olfactory stem cell in group 3 ( n = 9). Rats were followed for whisker movements and electroneuronography (ENoG) analyses. Results The whisker‐movement scores for group 3 were significantly different from other groups ( p < .001). ENoG showed that the amplitude values for group 3 were significantly different from group 1 and group 2 ( p = .030; p < .001). Group 3 showed marked olfactory stem cell under a fluorescence microscope. Conclusion This study suggests that olfactory stem cells may be used as a potent cellular therapy for accelerating the regeneration of peripheral nerve injuries. © 2016 Wiley Periodicals, Inc. Head Neck 38 : E2011–E2020, 2016

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