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Oncocytic carcinoma of the major salivary glands: A population‐based study of 278 cases
Author(s) -
Zhan Kevin Y.,
Lentsch Eric J.
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24363
Subject(s) - medicine , hazard ratio , salivary gland cancer , distant metastasis , confidence interval , lymph node metastasis , salivary gland , carcinoma , head and neck cancer , lymph node , parotid gland , cancer , population , head and neck , oncology , metastasis , pathology , surgery , environmental health
Background Oncocytic carcinomas of the major salivary glands are extremely rare, with <100 cases reported. Methods A retrospective review of the National Cancer Database was performed from 1998 to 2012. Results We found 278 cases of major salivary oncocytic carcinoma. Most patients were men (61.9%), white (84.8%), with parotid disease (88.5%). Median age was 67 years (range, 16–90 years). Regional and distant metastases were found in 36.4% and 4.7% of cases. Overall survival at 5 and 10‐years was 64% and 39%, respectively. Distant metastasis (hazard ratio [HR] = 13.87; 95% confidence interval [CI] = 2.98–64.52; p = .0010) and regional metastasis (HR = 3.01; 95% CI = 1.20–7.55; p = .019) are significant negative predictors, whereas positive margins approached significance (HR = 3.01; 95% CI = 1.20–7.55; p = .074). Conclusion Oncocytic carcinoma has a poor long‐term prognosis and lymph node metastases are common. Distant and regional metastases are significant predictors of decreased survival. © 2016 Wiley Periodicals, Inc. Head Neck 38 : E1981–E1986, 2016
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