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Near infrared fluorescent imaging after intravenous injection of indocyanine green during neck dissection in patients with head and neck cancer: A feasibility study
Author(s) -
Digonnet Antoine,
van Kerckhove Sophie,
Moreau Michel,
Willemse Esther,
Quiriny Marie,
Ahmed Bissan,
de Saint Aubain Nicolas,
Andry Guy,
Bourgeois Pierre
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24331
Subject(s) - indocyanine green , medicine , neck dissection , head and neck cancer , lymphatic system , dissection (medical) , lymph node , head and neck , surgery , lymph , fluorescence lifetime imaging microscopy , lesion , radiology , confidence interval , nuclear medicine , cancer , fluorescence , pathology , radiation therapy , physics , quantum mechanics
Background Indocyanine green (ICG) has not been studied during therapeutic lymph node dissections after intravenous injection. The purpose of this study was to explore the distribution of ICG in lymphatic nodes during neck dissection. Methods Eleven patients requiring neck dissection with or without resection of the primary lesion were included. ICG was intravenously injected at induction time of anesthesia. Imaging was performed before and after surgical resection. Fluorescence was measured in arbitrary units (AUs) in the pathology department. Mixed linear model and generalized estimating equations (GEEs) were used. Results Mean fluorescence of invaded nodes was 22.6 AUs (SD = 24.9) and 3.9 AUs (SD = 8.1) in negative nodes ( p = .016). After adjustment for the size of the node, the risk of invasion when fluorescence was observed was 12.2 (95% confidence interval [CI] = 5.3–28.2; p < .0001). Conclusion This study demonstrates the feasibility of ICG to bring a contrast during surgery between healthy and invaded nodes after i.v. injection. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E1833–E1837, 2016