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Definitive proton radiation therapy and concurrent cisplatin for unresectable head and neck adenoid cystic carcinoma: A series of 9 cases and a critical review of the literature
Author(s) -
Bhattasali Onita,
Holliday Emma,
Kies Merrill S.,
Hanna Ehab Y.,
Garden Adam S.,
Rosenthal David I.,
Morrison William H.,
Gunn G. Brandon,
Fuller C. David,
Zhu X. Ronald,
Frank Steven J.
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24262
Subject(s) - adenoid cystic carcinoma , medicine , head and neck , radiation therapy , proton therapy , radiology , oncology , carcinoma , surgery
Background The primary treatment for head and neck adenoid cystic carcinoma (ACC) is surgery. Infrequently, however, ACC's propensity for perineural and base of skull invasion can preclude definitive surgical management. We present our experience with proton radiation therapy (RT) and concurrent platinum‐based chemotherapy. Methods Nine patients with unresectable node‐negative, nonmetastatic head and neck ACC received definitive proton RT and concurrent cisplatin. Outcomes and toxicities were recorded. A systematic review of the literature was performed. Results Median follow‐up was 27 months (range, 9.2–48.3 months). Four patients achieved complete response at the primary site, and an additional 4 patients achieved stabilization of local disease. Only 1 patient developed local disease progression. Four patients had 5 acute grade 3 (G3) toxicities, and 1 patient developed a chronic G4 optic nerve disorder. Conclusion Our preliminary results suggest proton RT and concurrent chemotherapy is a definitive treatment option for select patients with head and neck ACC. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E1472–E1480, 2016