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Factors associated with the sensitivity of fine‐needle aspiration cytology for the diagnosis of follicular variant papillary thyroid carcinoma
Author(s) -
Chai Young Jun,
Suh Hyunsuk,
Yi Jin Wook,
Yu Hyeong Won,
Lee JoonHyop,
Kim Sujin,
Won JaeKyung,
Lee Kyu Eun
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24261
Subject(s) - medicine , group b , thyroid carcinoma , cytology , thyroid , fine needle aspiration , carcinoma , papillary carcinoma , stage (stratigraphy) , radiology , thyroidectomy , gastroenterology , pathology , biopsy , paleontology , biology
Background The purpose of this study was to evaluate the factors associated with diagnostic accuracy of preoperative fine‐needle aspiration (FNA) for follicular variant papillary thyroid carcinoma (FVPTC). Methods The patients with FVPTC who underwent thyroidectomy were divided into 2 groups: “group A” (Bethesda category II, III, or IV) versus “group B” (category V or VI). Results A total of 225 patients (117 in group A and 108 in group B) were included. Group B was associated with older age, malignant ultrasonographic features, smaller tumor size, extrathyroidal extension, higher stage, and B‐type Raf (BRAF) V600E mutation compared with group A. In multivariable analysis, malignant ultrasonographic features and tumor size ≤3.0 cm were independent predictive factors for group B. Conclusion FVPTCs >3.0 cm are unlikely to be diagnosed as category V or VI. Clinicians should keep FVPTC in mind and consider diagnostic lobectomy for the nodules regardless of FNA or ultrasonographic findings. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E1467–E1471, 2016