Premium
Extracranial/intracranial vascular bypass and craniofacial resection: New hope for patients with locally advanced recurrent nasopharyngeal carcinoma
Author(s) -
Chan Jimmy Yu Wai,
Wong Stanley Thian Sze,
Chan Richie Chiu Lung,
Wei William Ignace
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24234
Subject(s) - medicine , swallowing , nasopharyngeal carcinoma , craniofacial , quality of life (healthcare) , surgery , overall survival , radiation therapy , nursing , psychiatry
Background The purpose of this study was to investigate the oncologic outcome and quality of life after surgical treatment of locally advanced (rT3–rT4) recurrent nasopharyngeal carcinoma (NPC) using the staged extracranial/intracranial vascular bypass and combined craniofacial approach. Methods We conducted a prospective study. Results Between 1998 and 2013, 28 patients with rT3 to rT4 tumors were treated with the proposed surgical protocol. Clear resection margin was achieved in 46.4%. The median follow‐up was 42.6 months. The rate of local recurrence was 17.8%. The 5‐year overall survival was 52%. There was no change in the mean global health system score after the extensive surgery, although the physical functioning scores deteriorated significantly. The most common symptoms experienced by patients were speech and swallowing problems. Conclusion The proposed surgical treatment for locally advanced recurrent NPC was associated with satisfactory local tumor control and survival. Quality of life after surgery was reasonable, although multidisciplinary training was required to maximize the postoperative speech and swallowing function. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E1404–E1412, 2016