Premium
Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma
Author(s) -
Hirakawa Hitoshi,
Hanai Nobuhiro,
Ozawa Taijiro,
Suzuki Hidenori,
Nishikawa Daisuke,
Matayoshi Sen,
Suzuki Mikio,
Hasegawa Yasuhisa
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24217
Subject(s) - medicine , chemotherapy , pathological , oncology , neoadjuvant therapy , basal cell , head and neck , distant metastasis , metastasis , surgery , cancer , breast cancer
Background The significance of neoadjuvant chemotherapy followed by definitive surgery for sinonasal squamous cell carcinoma (SCC) was investigated using surgical specimens. Methods Surgery was performed in 58 patients, including 43 patients who had received neoadjuvant chemotherapy. The pathological response was classified as grades 0 (no effect), 1 (slight effect), 2 (moderate effect), and 3 (marked effect), and its correlation with prognosis was investigated. Results Grade 2 or 3 response was observed in 34.9% of cases that received neoadjuvant chemotherapy. Overall survival (OS), disease‐free survival (DFS), locoregional control, and freedom from distant metastasis were significantly better in the effective neoadjuvant chemotherapy group (grades 2 and 3) than in the less effective neoadjuvant chemotherapy group (grades 0 and 1) and the non‐neoadjuvant chemotherapy group combined. Conclusion Pathological response to neoadjuvant chemotherapy in sinonasal SCC was related to disease prognosis. © 2016 Wiley Periodicals, Inc. Head Neck 38 : E1305–E1311, 2016