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Risk of second primary malignancy after nasopharyngeal carcinoma in the United States: A population‐based study
Author(s) -
Chan Jason Y. K.,
Gooi Zhen,
Mydlarz Wojciech K.,
Agrawal Nishant
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24173
Subject(s) - medicine , nasopharyngeal carcinoma , pharynx , incidence (geometry) , confidence interval , malignancy , relative risk , carcinoma , cohort , epidemiology , population , nose , esophagus , cohort study , surgery , radiation therapy , physics , environmental health , optics
Background The purpose of this study was to evaluate the incidence of second primary malignancies in patients diagnosed with an index nasopharyngeal carcinoma (NPC) in the United States. Methods The cohort was assembled from the Surveillance, Epidemiology, and End Results (SEER) database with a primary NPC between 1973 and 2005. Results There was a 47% increased risk of second primary malignancy. The sites with increased risk include the oral cavity and pharynx (standardized incidence ratio [SIR] = 7.11; 95% confidence interval [CI] = 5.21–9.49), esophagus (SIR = 3.50; 95% CI = 1.68–6.44), nose, nasal cavity, and middle ear (SIR = 15.54; 95% CI = 5.70–33.83), and lung and bronchus (SIR = 2.39; 95% CI = 1.91–2.96). Conclusion Patients with NPC are likely at a significant risk for second primary malignancies, most notably in the oral cavity and pharynx, which is most likely related to genetic susceptibility, increased surveillance, and treatment effects. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E1130–E1136, 2016