Intestinal type adenocarcinoma of the ethmoid: Outcomes of a treatment regimen based on endoscopic surgery with or without radiotherapy | Zendy

Nicolai Piero | Zendy; Schreiber Alberto | Zendy; Bolzoni Villaret Andrea | Zendy; Lombardi Davide | Zendy; Morassi Laura | Zendy; Raffetti Elena | Zendy; Donato Francesco | Zendy; Battaglia Paolo | Zendy; Turri–Zai Mario | Zendy; Bignami Maurizio | Zendy; Castelnuovo Paolo | Zendy

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Intestinal type adenocarcinoma of the ethmoid: Outcomes of a treatment regimen based on endoscopic surgery with or without radiotherapy

Author(s) -

Nicolai Piero,

Schreiber Alberto,

Bolzoni Villaret Andrea,

Lombardi Davide,

Morassi Laura,

Raffetti Elena,

Donato Francesco,

Battaglia Paolo,

Turri–Zai Mario,

Bignami Maurizio,

Castelnuovo Paolo

Publication year - 2016

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.24144

Subject(s) - medicine , surgery , radiation therapy , regimen , cohort , proportional hazards model , adenocarcinoma , multivariate analysis , retrospective cohort study , survival analysis , cancer

Background The purpose of this study was to assess survival, prognostic factors, and complications in a cohort of patients with intestinal‐type adenocarcinoma (ITAC) treated with transnasal endoscopic surgery ± radiotherapy (RT). Methods Patients with ITAC who underwent endoscopic surgery ± RT at 2 tertiary centers were retrospectively reviewed. Overall survival (OS) and event‐free survival were calculated, and statistically significant variables were entered in a multivariate Cox regression model. Complications were also analyzed. Results One hundred‐sixty‐nine patients were included. Major complications occurred in 9.5% of patients. Adjuvant RT was delivered in 58.6% of patients. Five‐year OS and event‐free survival were 68.9% and 63.6%, respectively. Advanced pT classification, high‐grade, and positive surgical margins were independently predictive of poor survival. Conclusion Endoscopic surgery ± RT is a valid treatment option in most cases of ITAC. When compared with series based on external surgery, our results support a definitive paradigm shift in the management of ITAC. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E996–E1003, 2016

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