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Immortalization of epithelial cells in oral carcinogenesis as revealed by genome‐wide array comparative genomic hybridization: A meta‐analysis
Author(s) -
Vincent–Chong Vui King,
Salahshourifar Iman,
Razali Rozaimi,
Anwar Arif,
Zain Rosnah Binti
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24102
Subject(s) - comparative genomic hybridization , carcinogenesis , meta analysis , biology , genome , head and neck squamous cell carcinoma , genetics , computational biology , gene , cancer research , bioinformatics , pathology , cancer , medicine , head and neck cancer
Background This purpose of this meta‐analysis study was to identify the most frequent and potentially significant copy number alteration (CNA) in oral carcinogenesis. Methods Seven oral squamous cell carcinoma (OSCC)‐related publications, corresponding to 312 samples, were identified for this meta‐analysis. The data were analyzed in a 4‐step process that included the genome assembly coordination of multiple platforms, assignment of chromosomal position anchors, calling gains and losses, and functional annotation analysis. Results Gains were more frequent than losses in the entire dataset. High‐frequency gains were identified in chromosomes 5p, 14q, 11q, 7p, 17q, 20q, 8q, and 3q, whereas high‐frequency losses were identified in chromosomes 3p, 8p, 6p, 18q, and 4q. Ingenuity pathway analysis showed that the top biological function was associated with immortalization of the epithelial cells ( p = 1.93E‐04). Conclusion This study has identified multiple recurrent CNAs that are involved in various biological annotations associated with oral carcinogenesis. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E783–E797, 2016