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Past and future impact of next‐generation sequencing in head and neck cancer
Author(s) -
Sethi Neeraj,
MacLennan Kenneth,
Wood Henry M.,
Rabbitts Pamela
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24085
Subject(s) - sanger sequencing , dna sequencing , head and neck cancer , genomics , head and neck , computational biology , cancer , biology , genome , medicine , genetics , gene , surgery
Progress in sequencing technology is intrinsically linked to progress in understanding cancer genomics. The purpose of this review was to discuss the development from Sanger sequencing to next‐generation sequencing (NGS) technology. We highlight the technical considerations for understanding reports using NGS. We discuss the findings of studies in head and neck cancer using NGS as well as The Cancer Genome Atlas. Finally we discuss future routes for research utilizing this methodology and the potential impact of this. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E2395–E2402, 2016