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Indocyanine green fluorescence mapping of sentinel lymph node in patients with recurrent nasopharyngeal carcinoma after previous radiotherapy
Author(s) -
Chan Jimmy Yu Wai,
Tsang Raymond King Yin,
Wong Stanley Thian Sze,
Wei William Ignace
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24052
Subject(s) - lymph , medicine , indocyanine green , sentinel lymph node , neck dissection , lymph node , histopathology , nasopharyngeal carcinoma , malignancy , dissection (medical) , radiology , carcinoma , surgery , radiation therapy , pathology , cancer , breast cancer
Background The purpose of this study was to present the feasibility of indocyanine green (ICG) mapping of sentinel lymph node in recurrent nasopharyngeal carcinoma (NPC). M1ethods Peritumoral injection of 5‐mg ICG solution and real‐time mapping of the sentinel lymph nodes in the neck was performed during surgery. The sentinel lymph node identified was excised and sent separately for laboratory analysis. Selective neck dissection was then performed. The number and level of the sentinel lymph nodes, their signal‐to‐background ratio, and the histopathology of the sentinel lymph nodes and the neck dissection specimens were studied. Results A total of 5 patients were recruited into this study, of which 9 sentinel lymph nodes were identified. The majority of them were located in level II. The mean detection time after ICG injection was 288 seconds. The sentinel lymph nodes in 3 patients tested positive for malignancy. None of the selective neck dissection specimens harbored microscopic tumor deposits. Conclusion ICG mapping of sentinel lymph nodes in locally recurrent NPC is potentially feasible. It offers a better nodal staging in patients with clinically N0 disease status © 2015 Wiley Periodicals, Inc. Head Neck 37: E169–E173, 2015