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Rapid detection and destruction of squamous cell carcinoma of the head and neck by nano‐quadrapeutics
Author(s) -
Lukianova–Hleb Ekaterina Y.,
Lapotko Dmitri O.
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24018
Subject(s) - head and neck , head and neck squamous cell carcinoma , basal cell , medicine , oncology , nano , head and neck cancer , surgery , cancer , materials science , composite material
ABSTRACT Survival and quality of life remain poor for patients with head and neck squamous cell carcinoma (HNSCC) that cannot be fully resected safely, and form therapy‐resistant residual and recurrent tumors. We report novel cell‐level technology, quadrapeutics. Quadrapeutics converts surgery, drug, and radiation therapies into on‐demand microtreatment that unites the diagnosis and treatment in 1 rapid procedure by using 4 standard components: (1) targeted gold colloids; (2) liposomal drugs; (3) a laser pulse; and (4) radiation, all at safe doses. The therapeutic strength of quadrapeutics increases with cancer aggressiveness. In animal models of a primary and microscopic residual HNSCC, quadrapeutics increased the efficacy of standard chemoradiation therapy by more than 17‐fold by using only 3% to 6% of clinical doses of drug and radiation, did not cause side effects, and detected residual microtumors in vivo intraoperatively. Quadrapeutics can be applied to detect and eradicate HNSCC and similar microtumors in a safe and rapid theranostic procedure. © 2015 Wiley Periodicals, Inc. Head Neck 37: 1547–1555, 2015