Premium
Influence of body composition on survival in patients with head and neck cancer
Author(s) -
Karnell Lucy Hynds,
Sperry Steven M.,
Anderson Carryn M.,
Pagedar Nitin A.
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23983
Subject(s) - medicine , underweight , overweight , head and neck cancer , body mass index , obesity , proportional hazards model , survival rate , head and neck , cancer , oncology , surgery
Background Recent evidence has suggested links between obesity and outcomes for various types of cancer. This study investigates the impact that body composition has on survival in patients with head and neck cancer. Methods Data prospectively collected from 578 patients were analyzed using Cox regression models to determine independent associations that pretreatment body mass index (BMI) and 3‐month weight change have on observed survival. Results Higher BMIs were associated with better survival ( p < .001). Five‐year rates ranged from 33.8% for underweight to 75.3% for overweight/obese patients. Patients with stable weight had the highest 5‐year rate (72.6%; p = .019), whereas patients who gained ≥5% had worse survival (45.8%) than those who lost ≥5% (65.8%). BMI independently predicted survival, whereas weight change was not an independent predictor. Conclusion This demonstrated association between BMI and survival provides useful information when offering prognoses and investigating optimal treatments © 2015 Wiley Periodicals, Inc. Head Neck 38 : E261–E267, 2016