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Tumor deposits in head and neck carcinomas
Author(s) -
Sarioglu Sulen,
Akbulut Nilhan,
Iplikci Selen,
Aydin Barbaros,
Dogan Ersoy,
Unlu Mehtat,
Ellidokuz Hulya,
Ada Emel,
Akman Fadime,
Ikiz Ahmet Omer
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23981
Subject(s) - head and neck squamous cell carcinoma , medicine , pathological , lymphatic system , pathology , neck dissection , head and neck , lymph node , metastasis , lymphovascular invasion , basal cell , lymph , distant metastasis , primary tumor , carcinoma , oncology , head and neck cancer , cancer , surgery
Background Tumor deposits, nodules in the peritumoral adipose tissue with no architectural residue of lymph node, have previously been described in colorectal adenocarcinomas. To date, however, there has been no examination of tumor deposits in head and neck squamous cell carcinoma (HNSCC). Methods Neck dissection specimens of 140 patients with HNSCC were reevaluated for tumor deposits. Results Tumor deposits were detected in 24 cases (17%). Cases with tumor deposits had more lymphatic invasion ( p = .007), higher pathological N classification ( p = .00), and more frequently showed distant metastasis ( p = .003). Disease‐free and overall survival were significantly shorter for tumor deposit positive cases ( p = .016 and p = .005, respectively). Only tumor deposits were significant for overall survival. Tumor deposits increased the risk of recurrent disease 2294 times. Tumor deposits and pericapsular invasion were identified as independent prognostic markers; tumor deposits increased the risk of death from disease 3.4 times, whereas pericapsular invasion was associated with a 2.2‐fold increase in the risk of death. Conclusion These results highlight the existence of tumor deposits in neck dissection specimens of HNSCC and their association with poor prognosis. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E256–E260, 2016