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MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma
Author(s) -
Ganci Federica,
Sacconi Andrea,
Manciocco Valentina,
Sperduti Isabella,
Battaglia Paolo,
Covello Renato,
Muti Paola,
Strano Sabrina,
Spriano Giuseppe,
Fontemaggi Giulia,
Blandino Giovanni
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23969
Subject(s) - microrna , basal cell , carcinogenesis , squamous cell cancer , cancer , oncology , head and neck cancer , head and neck squamous cell carcinoma , gene expression profiling , biology , medicine , cancer research , gene , gene expression , genetics
Background Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with a high rate of recurrence. MicroRNAs (miRNAs) are gene regulators playing an important role in oral carcinogenesis. The purpose of this study was for us to identify and functionally characterize miRNAs that predict recurrence in OSCC. Methods We collected 92 OSCC with their normal tissue counterparts and we performed miRNAs expression profiling on 74 OSCC and 38 normal tissues. The association between the expression of miRNAs and clinical outcome was evaluated in the follow‐up of 69 patients. Results Four of the miRNAs deregulated between OSCC and normal tissues are prognostic for recurrence either when considered individually or as a group. Depletion of the expression of prognostic miRNAs inhibit the proliferation of OSCC cells Conclusion MiRNAs are differentially expressed in OSCC versus normal samples. The expression of 4 prognostic miRNA signatures is able to predict recurrence risk independently from other clinical factors in OSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E189–E197, 2016