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Pretreatment maximum standardized uptake value of 18 F‐fluorodeoxyglucose positron emission tomography as a predictor of distant metastasis in adenoid cystic carcinoma of the head and neck
Author(s) -
Kim Donghyun,
Kim Wontaek,
Lee Joohye,
Ki Yongkan,
Lee Byungjoo,
Cho Kyusup,
Kim Seongjang,
Nam Jiho,
Lee Jinchoon,
Kim Dongwon
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23953
Subject(s) - medicine , standardized uptake value , positron emission tomography , adenoid cystic carcinoma , fluorodeoxyglucose , nuclear medicine , radiology , radiation therapy , metastasis , carcinoma , distant metastasis , primary tumor , cancer
Background The purpose of this study was to determine whether the maximum standardized uptake value (SUVmax) of the primary tumor on pretreatment 18 F‐fluorodeoxyglucose positron emission tomography ( 18 F‐FDG PET) has prognostic significance in patients with adenoid cystic carcinoma (ACC) of the head and neck. Methods A retrospective review was carried out on 34 patients with ACC of the head and neck who underwent pretreatment 18 F‐FDG PET imaging from June 2005 through July 2009. All patients underwent surgery with curative intent, and 26 of them received adjuvant radiotherapy (RT). Results When subjects were stratified into 2 groups according to a cutoff value for SUVmax of 4.15, the risk of distant metastasis was significantly high in patients with high SUVmax (p = .014). Multivariate analysis showed that high SUVmax and histologic grade 3 were independent poor prognostic factors for distant metastasis‐free and disease‐free survival. Conclusion Pretreatment SUVmax of the primary tumor is an independent prognostic factor in patients with ACC of the head and neck. © 2015 Wiley Periodicals, Inc. Head Neck 38: 755–761, 2016