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Prognostic value of level IV metastases from head and neck squamous cell carcinoma
Author(s) -
Hoch Stephan,
Katabi Nour,
Daniel Hanna,
Franke Nora,
Wiegand Susanne,
Zimmerman Annette P.,
Mandapathil Magis,
Ferlito Alfio,
Teymoortash Afshin
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23861
Subject(s) - medicine , head and neck squamous cell carcinoma , neck dissection , head and neck , multivariate analysis , oncology , basal cell , overall survival , head and neck cancer , radiology , carcinoma , cancer , surgery
Background The purpose of this study was to evaluate the prognostic value of level IV metastases in head and neck squamous cell carcinoma (HNSCC). Methods The clinical and histopathological data of 111 patients with HNSCC with pN+ neck who underwent a primary tumor resection with unilateral or bilateral neck dissection were analyzed. Results Level IV metastases were histopathologically proven in 33 patients (29.7%). Pulmonary metastases were observed in 12 of 33 patients (36.4%) with level IV metastases, and in 13 of 78 patients (16.7%) without level IV metastases ( p = .04). Multivariate analyzes revealed a significant association between level IV metastases and pulmonary metastases ( p = .038). However, an influence on overall ( p = .65) or disease‐free survival ( p = .66) was not observed. Conclusion Level IV metastases seem to be a predictive factor for pulmonary metastases but not for overall and disease‐free survival in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: 140–146, 2016