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Sinus mucosa status in patients with nasopharyngeal carcinoma treated with intensity‐modulated radiotherapy: A 5‐year follow‐up
Author(s) -
Hsin ChungHan,
Tseng HsienChun,
Lin HuangPin,
Chen TsaiHsin
Publication year - 2016
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23849
Subject(s) - nasopharyngeal carcinoma , medicine , maxillary sinus , radiation therapy , sinusitis , ethmoid sinus , incidence (geometry) , sinus (botany) , retrospective cohort study , paranasal sinuses , carcinoma , radiology , surgery , physics , botany , biology , optics , genus
Background Sinus mucosa abnormalities on image studies, which is the major diagnostic measure for sinusitis, were investigated in patients with nasopharyngeal carcinoma (NPC) after intensity‐modulated radiotherapy (IMRT). Methods A retrospective review of the MRIs for patients with NPC was conducted. Sinus mucosa abnormalities were staged by the Lund–Mackay system. Results A total of 94 patients were enrolled in this study. The rate and severity of sinus abnormalities were highest on the third postradiotherapy month ( p < .005, t test). There was no significant increase in the incidence of abnormalities on the fifth postradiotherapy year ( t test). The anterior ethmoid and maxillary sinuses were the most affected sinuses before and after radiotherapy ( p < .005, chi‐square test). Conclusion Our data showed that the anterior ethmoid and maxillary sinuses were the most vulnerable sinuses for therapeutic toxicity after IMRT in patients with NPC. In the long run, however, the application of IMRT does not significantly increase the incidence of sinus toxicities. © 2015 Wiley Periodicals, Inc. Head Neck 38: 29–35, 2016