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Outcomes of nodal metastatic cutaneous squamous cell carcinoma of the head and neck treated in a regional center
Author(s) -
Schmidt Campbell,
Martin Jarad M.,
Khoo Eric,
Plank Ashley,
Grigg Roger
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23843
Subject(s) - medicine , immunosuppression , multivariate analysis , oncology , head and neck , incidence (geometry) , univariate analysis , head and neck cancer , nodal , retrospective cohort study , single center , basal cell , cancer , surgery , physics , optics
Background Given its metastatic potential and high incidence, cutaneous squamous cell carcinoma of the head and neck (SCCHN) has significant morbidity and mortality. Methods We conducted a retrospective review of prospectively collected data for 113 consecutive patients with nodal metastatic cutaneous SCCHN treated surgically with curative intent in a regional center. Survival curves were generated by the Kaplan–Meier method. Results Five‐year overall survival (OS), disease‐specific survival (DSS), and disease‐free survival (DFS) were 80%, 83%, and 75%, respectively. Twenty‐six patients (23%) relapsed, with 92% of relapses occurring within 2 years of surgery. Immunosuppression ( p = .008) and N classification ( p = .043) predicted decreased DFS on univariate analysis. On multivariate analysis, only immunosuppression independently predicted DFS ( p = .034). Conclusion This study validates the current N classification system, supports the adverse effect of immunosuppression, and suggests that intense follow‐up for 2 years postsurgery is warranted. Survival at this regional center is comparable to that achieved at metropolitan tertiary cancer centers. © 2015 Wiley Periodicals, Inc. Head Neck 37: 1808–1815, 2015