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Enteral glutamine supplementation in surgical patients with head and neck malignancy: A randomized controlled trial
Author(s) -
Azman Mawaddah,
Mohd Yunus Mohd Razif,
Sulaiman Suhaina,
Syed Omar Syed Nabil
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23839
Subject(s) - randomized controlled trial , enteral administration , head and neck , medicine , glutamine , malignancy , surgery , parenteral nutrition , biology , biochemistry , amino acid
Background Glutamine supplementation is a novel approach to perioperative nutritional management. Methods This study was a prospective randomized clinical trial of effects of enteral glutamine supplementation in surgical patients with head and neck malignancy in a tertiary center. This study measured the effects of supplementation within 4 weeks of the postoncologic surgical period in relation to fat‐free mass, serum albumin, and quality of life scores. Results The study population consisted of 44 patients. There was significant difference in serum albumin ( p < .001), fat‐free mass ( p < .001), and quality of life scores ( p < .05) between control and interventional groups. Significant correlation exists between fat‐free mass and quality of life score difference in our study population ( p < .05). Conclusion Enteral glutamine supplementation significantly improves fat‐free mass, serum albumin, and quality of life scores postoperatively and maintenance of lean body mass correlated with improved postoperative outcomes in terms of the patient's quality of life. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1799–1807, 2015