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Treatment outcome and prognostic factors of head and neck hemangiopericytoma: Meta‐analysis
Author(s) -
Wushou Alimujiang,
Miao Xinchao,
Shao Zhimin
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23812
Subject(s) - medicine , hazard ratio , hemangiopericytoma , odds ratio , head and neck , oncology , primary tumor , meta analysis , surgery , confidence interval , metastasis , radiology , cancer
Abstract Background Head and neck hemangiopericytoma (HNHPC) is rare. Treatment outcome and specific prognostic factors were unexplored. Methods A case meta‐analysis, in which treatment and outcome data were available, was performed. Results A total of 116 primary HNHPC cases were analyzed. Poor pathologic differentiation was associated with increased risk of tumor recurrence (odds ratio [OR] = 2.378; p = .005), metastasis (OR = 3.634; p = .011), and mortality (OR = 4.563; p = .002), whereas surgery was associated with decreased risk of tumor recurrence (OR = 0.109; p = .004). The tumor size >5.0 cm in diameter (hazard ratio [HR] = 6.391; p = .002), nonsurgical treatment (HR = 7.648; p = .000), and poor pathologic differentiation (HR = 1.705; p = .012) were the independent unfavorable prognostic factors for disease‐free survival. Moreover, nonsurgical treatment (HR = 8.097; p = .002) and deep tumor location (HR = 4.074; p = .013) were independent adverse prognostic factors for overall survival (OS). Conclusion These results suggest a management emphasizing the surgical removal of the tumor as first‐line treatment. Tumor size >5.0 cm, poor pathologic differentiation, deep tumor location, and nonsurgical treatment were independent adverse prognostic factors. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1685–1690, 2015