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Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus‐6 and human papillomavirus‐11
Author(s) -
Tjon Pian Gi Robin E. A.,
San Giorgi Michel R. M.,
Slagter–Menkema Lorian,
van Hemel Bettien M.,
van der Laan Bernard F. A. M.,
van den Heuvel Edwin R.,
Dikkers Frederik G.,
Schuuring Ed M.D.
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23808
Subject(s) - recurrent respiratory papillomatosis , medicine , human papillomavirus , retrospective cohort study
Background Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV)6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6‐ and HPV11‐associated RRP. Methods A retrospective cohort of 55 patients with RRP (1974–2012) was used. Surgical interventions ( n = 814) were analyzed, and complications scored. HPV6/11‐specific polymerase chain reaction (PCR) was performed on RRP biopsies. Results Seventy‐six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (<22.4 years) HPV11 group, and the older age (<22.4 years) HPV6 group. Regardless of HPV type, earlier age of onset of RRP resulted in a higher number of surgical interventions. Conclusion Anatomically, HPV11‐associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1625–1632, 2015