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Interactions between clinical factors, p16, and cyclin‐D1 expression and survival outcomes in oropharyngeal and hypopharyngeal squamous cell carcinoma
Author(s) -
Ang SiokHoon,
Haaland Benjamin,
Acharyya Sanchalika,
Thu Minn M. M.,
Krisna SaiSakktee,
Hwang SiokGek,
Tan PuayHoon,
Ng QuanSing,
Tan Daniel S. W.,
Tai WaiMeng,
Tan EngHuat,
Lim WanTeck,
Ang MeiKim
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23803
Subject(s) - medicine , cyclin d1 , oncology , head and neck squamous cell carcinoma , proportional hazards model , hypopharyngeal cancer , hazard ratio , gastroenterology , head and neck cancer , cancer , cell cycle , confidence interval
Background P16 and cyclin‐D1 are cell cycle proteins commonly dysregulated in head and neck carcinoma. We assessed their expression, clinicopathological variables, and overall survival (OS) in oropharyngeal and hypopharyngeal squamous cell carcinoma (SCC). Methods Clinical characteristics and p16 and cyclin‐D1 expression were evaluated in 101 patients with oropharyngeal SCC and 75 patients with hypopharyngeal SCC. Associations with OS were assessed using Cox regression and Kaplan–Meier analysis. Results Compared to oropharyngeal SCC, patients with hypopharyngeal SCC were older, men, ever‐smokers with higher mean Charlson Comorbidity Index (CCI), lower p16 expression, and poorer median OS (24.8 vs 62.3 months; p < .01). In oropharyngeal SCC, CCI ( p < .001), cyclin‐D1 (hazard ratio [HR] = 3.55; p = .007), current smoking (HR = 5.72; p = .004), and former smoking (HR = 4.12; p = .035) were independently associated with OS. In hypopharyngeal SCC, only nodal and Eastern Cooperative Oncology Group status were associated with OS. Conclusion In oropharyngeal SCC, cyclin‐D1 expression is correlated with survival, whereas smoking status and CCI may allow further stratification of outcome. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1650–1659, 2015