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Study of MET protein levels and MET gene copy number in 72 sinonasal intestinal‐type adenocarcinomas
Author(s) -
Projetti Fabrice,
Mesturoux Laura,
Coulibaly Béma,
Durand Karine,
Chaunavel Alain,
Léobon Sophie,
Gadeaud Emilie,
Caire François,
Bessède JeanPierre,
Labrousse François
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23795
Subject(s) - polysomy , carcinogenesis , biology , immunohistochemistry , adenocarcinoma , gene duplication , cancer research , gene , chromosome , pathology , fluorescence in situ hybridization , cancer , genetics , medicine , immunology
Background Sinonasal intestinal‐type adenocarcinomas (ITACs) have a poor prognosis, and are defined on the basis of their morphological similarities to colorectal adenocarcinomas. MET signaling pathway is involved in oncogenesis in various cancers. Nothing is currently known about the role of MET in ITACs. Methods In a series of 72 ITACs, we investigated MET protein levels by immunohistochemistry (IHC) and gene copy number by in situ hybridization. These findings were analyzed as a function of clinical data, histological typing, and patient outcome. Results MET protein was overproduced in 64% of cases and chromosome 7 polysomy was observed in 52% of cases. No tumor displayed MET amplification. The presence of mucinous or solid histological components, T3/T4 tumors, and incomplete resection were associated with a poor outcome. Conclusion MET is overproduced in about two third of ITACs, suggesting a role for the MET signaling pathway in the oncogenesis of these tumors. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1563–1568, 2015