Premium
T3‐T4 laryngeal cancer in The Netherlands Cancer Institute; 10‐year results of the consistent application of an organ‐preserving/‐sacrificing protocol
Author(s) -
Timmermans Adriana J.,
de Gooijer Cornedine J.,
Hamming–Vrieze Olga,
Hilgers Frans J.M.,
van den Brekel Michiel W.M.
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23789
Subject(s) - laryngectomy , medicine , cancer , retrospective cohort study , surgery , radiation therapy , stage (stratigraphy) , larynx , laryngeal neoplasm , biology , paleontology
Background Both organ‐preserving concurrent (chemo)radiotherapy ((C)RT) and organ‐sacrificing surgery (total laryngectomy) are used for treatment of advanced laryngeal cancer. The purpose of this study was to present the assessment of our treatment protocol for T3 (C)RT and T4 disease (total laryngectomy + postoperative RT). Methods We conducted a retrospective cohort study in 182 consecutive patients (1999–2008). The primary outcome was overall survival (OS) in relation to stage and treatment. Results One hundred two patients received RT (82.4% T3), 20 patients CRT (60.0% T3), and 60 patients total laryngectomy + RT (91.7% T4). Five‐year OS: T3 52%, T4 48%, for RT 50%, for CRT 43%, and for total laryngectomy + RT 52%. Five‐year laryngectomy‐free interval was 72% after RT, and 83% after CRT. Conclusion There were no differences in survival according to T classification or treatment modality. Because the majority of T3 laryngeal cancers were treated with (C)RT and the majority of T4 with total laryngectomy + RT, this gives food for thought on whether the present protocol for T3 laryngeal cancer is optimal. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1495–1503, 2015