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In‐office cup biopsy and laryngeal cytology versus operating room biopsy for the diagnosis of pharyngolaryngeal tumors: Efficacy and cost‐effectiveness
Author(s) -
Castillo Farías Felipe,
Cobeta Ignacio,
Souviron Rosalia,
Barberá Rafael,
Mora Elena,
Benito Amparo,
Royuela Ana
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23781
Subject(s) - medicine , biopsy , cytology , radiology , predictive value , malignancy , larynx , confidence interval , laryngoscopy , surgery , pathology , intubation
Background In‐office biopsy is an effective technique to diagnose the nature of pharyngolaryngeal lesions. Methods We selected patients with pharyngolaryngeal lesions suspicious for malignancy. For in‐office biopsy procedures, laryngeal cytology and direct laryngoscopy biopsy were performed, and diagnostic parameters and costs were estimated. Results Eighty‐eight patients were selected for this study. For laryngeal cytology, sensitivity was 70.3% (95% confidence interval [CI] = 59.9% to 80.7%), specificity 100% with a positive predictive value of 100% and a negative predictive value of 50% (95% CI = 35.2% to 64.8%). In‐office biopsy sensitivity was 81% (95% CI = 72.6% to 89.3%), specificity 100% with a positive predictive value of 100% and a negative predictive value of 20% (95% CI = 2.5% to 37.5%). At our hospital, the use of in‐office biopsies as a first approach for diagnosis saves $50,140.80 U.S. per annum. Conclusion In‐office biopsy is a more affordable technique that enables histologic diagnosis of pharyngolaryngeal lesions in a large percentage of patients. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1483–1487, 2015