Premium
Meta‐analysis of 18 fluorodeoxyglucose positron emission tomography‐CT for diagnosis of lung malignancies in patients with head and neck squamous cell carcinomas
Author(s) -
Xi Kai,
Xie Xiaojuan,
Xi Shoumin
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23774
Subject(s) - medicine , diagnostic odds ratio , confidence interval , receiver operating characteristic , odds ratio , positron emission tomography , likelihood ratios in diagnostic testing , meta analysis , lung cancer , head and neck squamous cell carcinoma , nuclear medicine , radiology , head and neck cancer , area under the curve , oncology , cancer
Background The purpose of this meta‐analysis was to evaluate the accuracy of 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)‐CT for diagnosis of lung malignancies in patients with head and neck squamous cell carcinomas (HNSCCs). Methods A systematic review of relevant literature was performed in the MEDLINE and EMBASE databases. The Stata software was used to pool the sensitivity, specificity, diagnostic odds ratio, and likelihood ratios, and to construct summary receiver operating characteristic (ROC) curves for 18 FDG PET‐CT. Results Twelve articles (1431 patients) were included in this study. The pooled sensitivity, specificity, diagnostic odds ratio, positive likelihood ratio, and negative likelihood ratio with 95% confidence interval (CI) for 18 FDG PET‐CT were 0.85 (95% CI = 0.66–0.94), 0.98 (95% CI = 0.96–0.99), 335 (95% CI = 96.4–1166), 52.0 (95% CI = 23.3–115.9), and 0.16 (95% CI = 0.06–0.43), respectively. Area under the curve was 0.99 (95% CI = 0.97–0.99). Conclusion 18 FDG PET‐CT is a valuable diagnostic tool for diagnosing lung malignancies in patients with HNSCC. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1680–1684, 2015