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Acute and late side effects to salivary glands and oral mucosa after head and neck radiotherapy in children and adolescents. Results of the “Registry for the evaluation of side effects after radiotherapy in childhood and adolescence”
Author(s) -
Bölling Tobias,
Weege Julia,
Eich Hans Theodor,
Timmermann Beate,
Meyer FrankMichal,
Rübe Christian,
Kortmann RolfDieter,
Fischedick Karin,
Rödel Claus,
Koch Raphael,
Willich Normann
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23715
Subject(s) - medicine , radiation therapy , head and neck , acute toxicity , head and neck cancer , side effect (computer science) , toxicity , oral mucosa , odds ratio , surgery , pathology , computer science , programming language
Background The registry for the evaluation of side effects after radiotherapy in childhood and adolescence (RiSK) was established to prospectively characterize radiation‐associated side effects. The purpose of this analysis was to characterize side effects after radiotherapy to the head and neck in children and adolescents. Methods Radiation doses have been collected across Germany since 2001. Acute and late side effects were characterized. Results Until January 2010, 133 patients (median age, 12.7 years) were recruited who had received radiotherapy to the salivary glands. Toxicity evaluation was available for 114 patients (median follow‐up, 2.9 years). Acute and late toxicity significantly depended on the maximum radiation dose to the salivary glands. An increase of the mean value of maximum dose of 1 Gray (Gy) to the submandibular glands resulted in an odds ratio of 1.04 (range, 1.00–1.08; p = .039) for acute toxicities of the salivary glands and 1.08 (range, 1.03–1.13; p = .001) for acute mucosal toxicities. Conclusion These data can be used for an individual risk assessment in pediatric head and neck radiotherapy. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1137–1141, 2015