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Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study
Author(s) -
Amit Moran,
Binenbaum Yoav,
Sharma Kanika,
Ramer Naomi,
Ramer Ilana,
Agbetoba Abib,
Glick Joelle,
Yang Xinjie,
Lei Delin,
Bjørndal Kristine,
Godballe Christian,
Mücke Thomas,
Wolff KlausDietrich,
Fliss Dan,
Eckardt André M.,
Copelli Chiara,
Sesenna Enrico,
Palmer Frank,
Ganly Ian,
Patel Snehal,
Gil Ziv
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23711
Subject(s) - medicine , adenoid cystic carcinoma , neck dissection , incidence (geometry) , adenoid , multivariate analysis , cervical lymph nodes , occult , lymph node , metastasis , survival rate , radiology , carcinoma , surgery , cancer , pathology , physics , alternative medicine , optics
Background The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. Methods We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. Results The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% ( p = .001). The rate of occult nodal metastases was 17%. Overall 5‐year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively ( p = .017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. Conclusion Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1032–1037, 2015