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Chemoradiation therapy for squamous cell carcinoma of the external auditory canal: A meta‐analysis
Author(s) -
Takenaka Yukinori,
Cho Hironori,
Nakahara Susumu,
Yamamoto Yoshifumi,
Yasui Toshimichi,
Inohara Hidenori
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23698
Subject(s) - medicine , auditory canal , meta analysis , radiation therapy , surgery , survival rate , carcinoma
Background The standard treatment for advanced external auditory canal squamous cell carcinoma (SCC) is subtotal temporal bone resection and postoperative radiation therapy (RT), whereas chemoradiation therapy (CRT) is used in some institutions to improve patient prognosis. The purpose of this study was to evaluate the efficacy of CRT in external auditory canal SCC treatment. Methods Meta‐analyses of external auditory canal SCC studies were performed. We extracted 5‐year overall survival rates and number of patients for aggregate patient data, and types of treatment and outcomes for individual patient data. Results The 5‐year overall survival rate of 752 patients was 57%. In the individual patient data meta‐analysis, the 5‐year overall survival rates of patients who received surgery ± RT, preoperative CRT, definitive CRT, and postoperative CRT were 53.5%, 85.7%, 43.6%, and 0%, respectively. Conclusion Our data suggest that preoperative CRT may improve the survival of surgically treated patients with external auditory canal SCC and that definitive CRT may be equivalent to surgical resection. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1073–1080, 2015