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Squamous cell carcinoma of the tonsil managed by conventional surgery and postoperative radiation
Author(s) -
Rahmati Rahmatullah,
Dogan Snjezana,
Pyke Owen,
Palmer Frank,
Awad Mahmoud,
Lee Nancy,
Kraus Dennis H.,
Shah Jatin P.,
Patel Snehal G.,
Ganly Ian
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23679
Subject(s) - medicine , lymphovascular invasion , tonsil , multivariate analysis , univariate analysis , stage (stratigraphy) , t stage , pathological , surgery , oncology , basal cell , head and neck cancer , radiation therapy , cancer , metastasis , biology , paleontology
Background The purpose of this study was to report the long‐term outcome of patients with squamous cell cancer (SCC) of the tonsil managed by surgery followed by postoperative radiotherapy (PORT). Methods Eighty‐eight patients treated between 1985 and 2005 were analyzed. Overall survival (OS), disease‐specific survival (DSS), and recurrence‐free survival (RFS) were determined by the Kaplan–Meier method. Factors predictive of outcome were determined by univariate and multivariate analysis. Results Forty‐eight percent of patients had T3 to T4 disease and 75% had a positive neck. Five‐year OS, DSS, and RFS were 66%, 82%, and 80%, respectively. The status of the neck was not predictive of outcome (DSS 80% for N0 vs 82% for N+; p = .97). Lymphovascular invasion was an independent predictor of OS, DSS, and RFS on multivariate analysis. Conclusion Lymphovascular invasion but not pathological stage of the neck is an independent predictor of outcome in patients with tonsillar SCC. © 2014 Wiley Periodicals, Inc. Head Neck 37: 800–807, 2015