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Treatment outcomes of postradiation second head and neck malignancies managed by a multidisciplinary approach
Author(s) -
Chung Joseph,
Lee Victor,
Tsang Raymond,
Chan Jimmy,
Kwong Dora L. W.,
Lam Kaon,
Sze Henry C. K.,
Leung Towai
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23674
Subject(s) - medicine , malignancy , head and neck , radiation therapy , sarcoma , multivariate analysis , oncology , head and neck cancer , radical surgery , chemotherapy , surgery , cancer , pathology
Background The purpose of this study was to report on the treatment outcomes of patients with postradiation second head and neck malignancies. Methods Fifty‐seven consecutive patients with postradiation second malignancy were reviewed. Progression‐free survival (PFS), overall survival (OS), and prognostic factors were analyzed. Results Mean time interval between first course of radiation therapy to the development of postradiation second malignancy was 13.2 years. Median PFS and OS for the whole group were 12.0 and 67.0 months, respectively. Postradiation sarcoma conferred a worse PFS ( p = .003) and OS ( p = .001) as compared to postradiation carcinoma. Multivariate analysis revealed that Eastern Cooperative Oncology Group (ECOG) performance status ≥3 ( p = .034), postradiation sarcoma ( p = .007), and lack of radical surgery ( p = .044) are prognostic of PFS, whereas postradiation sarcoma ( p = .002), lack of postprogression surgery ( p < .001), and lack of postprogression systemic therapy ( p = .011) were prognostic factors of OS. Conclusion Treatment outcomes of postradiation second malignancy seemed promising under a multidisciplinary management. © 2014 Wiley Periodicals, Inc. Head Neck 37: 815–822, 2015