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Outcomes of intensity‐modulated radiotherapy versus conventional radiotherapy for hypopharyngeal cancer
Author(s) -
Mok Gary,
Gauthier Isabelle,
Jiang Haiyan,
Huang Shao Hui,
Chan Kelvin,
Witterick Ian J.,
O'Sullivan Brian,
Waldron John N.,
Bayley Andrew J.,
Cho B. C. John,
Cummings Bernard J.,
Dawson Laura A.,
Hope Andrew J.,
Kim John J.,
Ringash Jolie
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23649
Subject(s) - medicine , hypopharyngeal cancer , radiation therapy , larynx , feeding tube , head and neck cancer , chemoradiotherapy , surgery
Background The purpose of this study was to discuss if the adoption of intensity‐modulated radiotherapy (IMRT) for hypopharyngeal squamous cell carcinoma (SCC) has improved the outcome. Methods We compared 3‐dimensional (3D) radiotherapy (RT) and IMRT in all patients with hypopharyngeal SCC treated with curative intent RT or chemoradiation therapy (CRT) from January 1, 2000, to February 28, 2010. Locoregional control, overall survival (OS), distant relapse rate, larynx preservation rate, and enteral feeding tube duration were analyzed. Results Of 181 consecutive patients, 90 received 3D‐RT and 91 received IMRT. At 3 years, the IMRT group had higher locoregional control compared with the 3D‐RT group (75% vs 58%; p = .003), but similar OS (50% vs 52%; p = .99), distant relapse rate (23% vs 20%; p = .79), and larynx‐preservation rate (90% vs 86%; p = .16). The 2‐year enteral feeding tube dependency rate was similar in both groups (19% vs 18%; p = .12). Conclusion Patients with hypopharyngeal SCC treated with IMRT showed a higher locoregional control compared with 3D‐RT. However, distant‐relapse rate and OS remain comparable between treatment techniques. © 2014 Wiley Periodicals, Inc. Head Neck 37: 655–661, 2015