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Clinicopathologic factors and adjuvant treatment effects on survival in adult head and neck synovial cell sarcoma
Author(s) -
Crowson Matthew G.,
Lalich Ian,
Keeney Michael G.,
Garcia Joaquin J.,
Price Daniel L.
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23605
Subject(s) - synovial sarcoma , medicine , head and neck , sarcoma , oncology , adjuvant chemotherapy , overall survival , adjuvant , head and neck cancer , pathology , radiation therapy , surgery , cancer , breast cancer
Background Synovial cell sarcoma is a rare soft tissue sarcoma. The purpose of this study was to investigate clinicopathologic factors and management on survival in primary synovial sarcoma of the head and neck. Methods We conducted a retrospective case series of medical records. Standard Kaplan–Meier survival analyses and accompanying log‐rank tests were used. Results Twenty‐eight patients were identified. All patients had surgery in attempt to remove the primary lesion. Nine patients received adjuvant radiation therapy, 2 received chemotherapy, and 14 received chemoradiation therapy postoperatively. Metastases on initial presentation and tumor size >4 cm decreased survival. No significant effect on overall survival or local tumor recurrence with histologic subtype, lymph node involvement at diagnosis, tumors >5 cm, or when comparing adjuvant therapy types. Conclusion Although surgery remains the mainstay of treatment, our results do not suggest that adding chemotherapy to postoperative radiotherapy confers a survival or control benefit. © 2014 Wiley Periodicals, Inc. Head Neck 37: 375–380, 2015