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Prognostic model for distant metastasis in locally advanced nasopharyngeal carcinoma after concurrent chemoradiotherapy
Author(s) -
Chen Chuangzhen,
Chen Siqia,
Le QuynhThu,
Chen Jianzhou,
Chen Zhijian,
Li Dongsheng,
Zhou Mingzhen,
Li Derui
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23583
Subject(s) - nasopharyngeal carcinoma , medicine , distant metastasis , chemoradiotherapy , oncology , metastasis , adjuvant , chemotherapy , adjuvant chemotherapy , radiation therapy , cancer , breast cancer
Background A prognostic model should be established for distant metastasis in locally advanced nasopharyngeal carcinoma (NPC) after concurrent chemoradiotherapy (CCRT). Methods Patients with locally advanced NPC who received CCRT were divided into a construction set (230 patients) and a validating set (115 patients). The constructed index was derived on the former and then tested on the latter. Results The prognostic score was defined as the number of adverse prognostic factors: age >45, N 3 category, hemoglobin <11.0 g/dL and lactate dehydrogenase ≥240 U/L. The score predicted the 5‐year distant metastasis–free survival as follows: 0, 91%; 1, 74%; 2, 51%; and ≥3, 12%. In the validating set, the observed 5‐year distant metastasis‐free survival of these 4 groups with scores of 0, 1, 2, 3, or higher were 81%, 68%, 47%, and 15%, respectively. Conclusion The established model might be useful for predicting the risk of distant metastasis in patients with locally advanced NPC who underwent CCRT and may identify the patients' need for intensified adjuvant chemotherapy. © 2014 Wiley Periodicals, Inc. Head Neck 37 : 209‐214, 2015