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Clinical features and outcomes of young patients with head and neck non‐rhabdomyosarcoma soft tissue sarcomas
Author(s) -
Federico Sara M.,
Gilpin David,
Samant Sandeep,
Billups Catherine A.,
Spunt Sheri L.
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23564
Subject(s) - medicine , rhabdomyosarcoma , head and neck , soft tissue sarcoma , soft tissue , sarcoma , radiation therapy , lymph node , medical record , presentation (obstetrics) , chemotherapy , overall survival , surgery , radiology , pathology
Background The history, prognostic factors, and outcome of young patients with head and neck non‐rhabdomyosarcoma soft tissue sarcoma (NRSTS) have not been adequately characterized. Methods Medical records of 58 patients with head and neck NRSTS treated at St. Jude Children's Research Hospital were reviewed. Results The majority of tumors were ≤5 cm and high grade. Lymph node and/or distant metastases were present in 17% at presentation. Patients received a combination of surgery, chemotherapy, and radiotherapy. The 10‐year event‐free and survival rates were 53.1% ± 7.3% and 63.2% ± 7.1%, respectively. Features associated with inferior survival included high histologic grade ( p = .006), tumor diameter >5 cm ( p < .001), invasiveness ( p < .001), and incomplete resection at diagnosis ( p = .005). Conclusion Most head and neck NRSTS in young patients are small, high grade, and nonmetastatic. The outcome is poor compared to NRSTS at other anatomic sites. Innovative approaches to local control and improved systemic therapy are needed. © 2014 Wiley Periodicals, Inc. Head Neck 37 : 76–83, 2015