Premium
Matrix metalloproteinase‐7 and matrix metalloproteinase‐25 in oral tongue squamous cell carcinoma
Author(s) -
Mäkinen Laura K.,
Häyry Valtteri,
Hagström Jaana,
Sorsa Timo,
Passador–Santos Fabricio,
Keski–Säntti Harri,
Haukka Jari,
Mäkitie Antti A.,
Haglund Caj,
Atula Timo
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23539
Subject(s) - matrix metalloproteinase , immunohistochemistry , medicine , tongue , pathology , immunostaining , stage (stratigraphy) , metastasis , tissue microarray , oncology , cancer , biology , paleontology
Background Predicting the clinical course of early‐stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP‐7 and MMP‐25 in oral tongue SCC. Methods We used tissue microarray (TMA) technique and immunohistochemistry to study the expression of MMP‐7 and MMP‐25 in 73 patients with stage I to II oral tongue SCC and compared their immunoexpressions with clinical data. Results Immunohistochemistry revealed MMP‐7 and MMP‐25 expression in 90% ( n = 63 of 70) and 90% ( n = 64 of 71) of the tumors, respectively. MMP‐7 protein expression was associated with presence of occult cervical metastases (odds ratio [OR], 3.67; p = .013), increased invasion depth (OR, 4.60; p = .005), and higher tumor grade (OR, 3.30; p = .007). MMP‐7 expression was predictive for poor outcome ( p = .021). Immunostaining of MMP‐25 did not correlate with any clinical parameters. Conclusion We conclude that MMP‐7, but not MMP‐25, expression may have prognostic significance in early‐stage oral tongue SCC. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1783–1788, 2014